2IAY

Crystal structure of a duf1831 family protein (lp2179) from lactobacillus plantarum at 1.20 A resolution

Summary for 2IAY

• Entry DOI: 10.2210/pdb2iay/pdb
• Descriptor: Hypothetical protein, CHLORIDE ION, GLYCEROL, ... (4 entities in total)
• Functional Keywords: structural genomics, joint center for structural genomics, jcsg, protein structure initiative, psi-2, translation
• Biological source: Lactobacillus plantarum
• Total number of polymer chains: 1
• Total formula weight: 12998.55

Authors

Joint Center for Structural Genomics (JCSG) (deposition date: 2006-09-08, release date: 2006-10-10, Last modification date: 2024-11-06)

Primary citation

Bakolitsa, C.,Kumar, A.,Carlton, D.,Miller, M.D.,Krishna, S.S.,Abdubek, P.,Astakhova, T.,Axelrod, H.L.,Chiu, H.J.,Clayton, T.,Deller, M.C.,Duan, L.,Elsliger, M.A.,Feuerhelm, J.,Grzechnik, S.K.,Grant, J.C.,Han, G.W.,Jaroszewski, L.,Jin, K.K.,Klock, H.E.,Knuth, M.W.,Kozbial, P.,Marciano, D.,McMullan, D.,Morse, A.T.,Nigoghossian, E.,Okach, L.,Oommachen, S.,Paulsen, J.,Reyes, R.,Rife, C.L.,Tien, H.J.,Trout, C.V.,van den Bedem, H.,Weekes, D.,Xu, Q.,Hodgson, K.O.,Wooley, J.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Wilson, I.A.
Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism.
Acta Crystallogr.,Sect.F, 66:1205-1210, 2010

PubMed Abstract: The structure of LP2179, a member of the PF08866 (DUF1831) family, suggests a novel α+β fold comprising two β-sheets packed against a single helix. A remote structural similarity to two other uncharacterized protein families specific to the Bacillus genus (PF08868 and PF08968), as well as to prokaryotic S-adenosylmethionine decarboxylases, is consistent with a role in amino-acid metabolism. Genomic neighborhood analysis of LP2179 supports this functional assignment, which might also then be extended to PF08868 and PF08968.

PubMed: 20944212
DOI: 10.1107/S1744309109023689

Experimental method

X-RAY DIFFRACTION (1.2 Å)