2I7T

Structure of human CPSF-73

Summary for 2I7T

Entry DOI	10.2210/pdb2i7t/pdb
Related	2I7V 2I7X
Descriptor	Cleavage and polyadenylation specificity factor 73 kDa subunit, ZINC ION, SULFATE ION, ... (4 entities in total)
Functional Keywords	polyadenylation, metallo-b-lactamase, pre-mrna processing, artemis, v(d)j recombination, double-strand break repair, hydrolase, rna binding protein
Biological source	Homo sapiens (human)
Cellular location	Nucleus : Q9UKF6
Total number of polymer chains	1
Total formula weight	52529.79
Authors	Mandel, C.R.,Zhang, H.,Tong, L. (deposition date: 2006-08-31, release date: 2007-01-30, Last modification date: 2024-02-21)
Primary citation	Mandel, C.R.,Kaneko, S.,Zhang, H.,Gebauer, D.,Vethantham, V.,Manley, J.L.,Tong, L. Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. Nature, 444:953-956, 2006 Cited by PubMed: 17128255 DOI: 10.1038/nature05363 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation