2I4Z

Crystal structure of the complex between PPARgamma and the partial agonist LT127 (ureidofibrate derivative). This structure has been obtained from crystals soaked for 6 hours.

2I4Z の概要

• エントリーDOI: 10.2210/pdb2i4z/pdb
• 関連するPDBエントリー: 1PRG 2I4J 2PRG 4PRG
• 分子名称: Peroxisome proliferator-activated receptor gamma, (2S)-2-(4-{2-[1,3-BENZOXAZOL-2-YL(HEPTYL)AMINO]ETHYL}PHENOXY)-2-METHYLBUTANOIC ACID (3 entities in total)
• 機能のキーワード: bundle of alpha-helices and a small four-stranded beta-sheet, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65513.89

構造登録者

Pochetti, G.,Mazza, F. (登録日: 2006-08-23, 公開日: 2007-04-17, 最終更新日: 2023-08-30)

• 主引用文献: Pochetti, G.,Godio, C.,Mitro, N.,Caruso, D.,Galmozzi, A.,Scurati, S.,Loiodice, F.,Fracchiolla, G.,Tortorella, P.,Laghezza, A.,Lavecchia, A.,Novellino, E.,Mazza, F.,Crestani, M.; Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands; J.Biol.Chem., 282:17314-17324, 2007; PubMed: 17403688; DOI: 10.1074/jbc.M702316200

実験手法

X-RAY DIFFRACTION (2.25 Å)