2I3Z

rat DPP-IV with xanthine mimetic inhibitor #7

Summary for 2I3Z

Related2GBI
DescriptorDipeptidyl peptidase 4 (Dipeptidyl peptidase IV) (DPP IV), 2-[(3S)-3-AMINOPIPERIDIN-1-YL]-1-(2-CYANOBENZYL)-5-METHYL-4,6-DIOXO-3,4,5,6-TETRAHYDROPYRROLO[3,4-D]IMIDAZOL-1-IUM (2 entities in total)
Functional Keywordsenzyme, peptidase, inhibitor, hydrolase
Biological sourceRattus norvegicus (Norway rat)
Cellular locationDipeptidyl peptidase 4 soluble form: Secreted. Cell membrane; Single-pass type II membrane protein P14740
Total number of polymer chains2
Total molecular weight169040.57
Authors
Primary citation
Kurukulasuriya, R.,Rohde, J.J.,Szczepankiewicz, B.G.,Basha, F.,Lai, C.,Jae, H.S.,Winn, M.,Stewart, K.D.,Longenecker, K.L.,Lubben, T.W.,Ballaron, S.J.,Sham, H.L.,von Geldern, T.W.
Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors.
Bioorg.Med.Chem.Lett., 16:6226-6230, 2006
PubMed: 17010607 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2006.09.024
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.282273.3%7.0%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload