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2I3Z

rat DPP-IV with xanthine mimetic inhibitor #7

Functional Information from GO Data
ChainGOidnamespacecontents
A0001618molecular_functionvirus receptor activity
A0001662biological_processbehavioral fear response
A0001666biological_processresponse to hypoxia
A0002020molecular_functionprotease binding
A0002337biological_processB-1a B cell differentiation
A0002709biological_processregulation of T cell mediated immunity
A0002717biological_processpositive regulation of natural killer cell mediated immunity
A0004177molecular_functionaminopeptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005102molecular_functionsignaling receptor binding
A0005518molecular_functioncollagen binding
A0005576cellular_componentextracellular region
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0007155biological_processcell adhesion
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0008239molecular_functiondipeptidyl-peptidase activity
A0008284biological_processpositive regulation of cell population proliferation
A0009986cellular_componentcell surface
A0010716biological_processnegative regulation of extracellular matrix disassembly
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016787molecular_functionhydrolase activity
A0030027cellular_componentlamellipodium
A0030139cellular_componentendocytic vesicle
A0030163biological_processprotein catabolic process
A0031258cellular_componentlamellipodium membrane
A0031295biological_processT cell costimulation
A0033632biological_processregulation of cell-cell adhesion mediated by integrin
A0035641biological_processlocomotory exploration behavior
A0036343biological_processpsychomotor behavior
A0042110biological_processT cell activation
A0042277molecular_functionpeptide binding
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042995cellular_componentcell projection
A0043542biological_processendothelial cell migration
A0045121cellular_componentmembrane raft
A0045499molecular_functionchemorepellent activity
A0046581cellular_componentintercellular canaliculus
A0046718biological_processsymbiont entry into host cell
A0050919biological_processnegative chemotaxis
A0070161cellular_componentanchoring junction
A0090024biological_processnegative regulation of neutrophil chemotaxis
B0001618molecular_functionvirus receptor activity
B0001662biological_processbehavioral fear response
B0001666biological_processresponse to hypoxia
B0002020molecular_functionprotease binding
B0002337biological_processB-1a B cell differentiation
B0002709biological_processregulation of T cell mediated immunity
B0002717biological_processpositive regulation of natural killer cell mediated immunity
B0004177molecular_functionaminopeptidase activity
B0004252molecular_functionserine-type endopeptidase activity
B0005102molecular_functionsignaling receptor binding
B0005518molecular_functioncollagen binding
B0005576cellular_componentextracellular region
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0007155biological_processcell adhesion
B0008233molecular_functionpeptidase activity
B0008236molecular_functionserine-type peptidase activity
B0008239molecular_functiondipeptidyl-peptidase activity
B0008284biological_processpositive regulation of cell population proliferation
B0009986cellular_componentcell surface
B0010716biological_processnegative regulation of extracellular matrix disassembly
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0016787molecular_functionhydrolase activity
B0030027cellular_componentlamellipodium
B0030139cellular_componentendocytic vesicle
B0030163biological_processprotein catabolic process
B0031258cellular_componentlamellipodium membrane
B0031295biological_processT cell costimulation
B0033632biological_processregulation of cell-cell adhesion mediated by integrin
B0035641biological_processlocomotory exploration behavior
B0036343biological_processpsychomotor behavior
B0042110biological_processT cell activation
B0042277molecular_functionpeptide binding
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042995cellular_componentcell projection
B0043542biological_processendothelial cell migration
B0045121cellular_componentmembrane raft
B0045499molecular_functionchemorepellent activity
B0046581cellular_componentintercellular canaliculus
B0046718biological_processsymbiont entry into host cell
B0050919biological_processnegative chemotaxis
B0070161cellular_componentanchoring junction
B0090024biological_processnegative regulation of neutrophil chemotaxis
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE LIR A 900
ChainResidue
AARG123
ATYR663
ATYR667
AASN711
AGLU203
AGLU204
APHE355
ATYR548
ATRP630
ASER631
ATYR632
AVAL657

Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. MAICdyDkTTLVWNC
ChainResidueDetails
AMET323-CYS337

site_idPS00708
Number of Residues31
DetailsPRO_ENDOPEP_SER Prolyl endopeptidase family serine active site. DqieAarqFlkmgfvdskrvaiwGwSyGGYV
ChainResidueDetails
AASP606-VAL636

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU10084
ChainResidueDetails
ASER631
AASP709
AHIS741
BSER631
BASP709
BHIS741

site_idSWS_FT_FI2
Number of Residues10
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16768443
ChainResidueDetails
AASN83
AASN90
AASN227
AASN319
AASN521
BASN83
BASN90
BASN227
BASN319
BASN521

site_idSWS_FT_FI3
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000250
ChainResidueDetails
AASN148
AASN217
AASN686
BASN148
BASN217
BASN686

218500

PDB entries from 2024-04-17

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