2I0E

Structure of catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor

2I0E の概要

• エントリーDOI: 10.2210/pdb2i0e/pdb
• 分子名称: Protein Kinase C-beta II, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-2-METHYL-1H-INDOL-3-YL}-4-(2-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE (3 entities in total)
• 機能のキーワード: protein kinase c beta ii, protein kinase c, serine/threonine protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): P05771
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82473.79

構造登録者

Grodsky, N.B.,Love, R.L. (登録日: 2006-08-10, 公開日: 2006-11-14, 最終更新日: 2024-04-03)

• 主引用文献: Grodsky, N.,Li, Y.,Bouzida, D.,Love, R.,Jensen, J.,Nodes, B.,Nonomiya, J.,Grant, S.; Structure of the Catalytic Domain of Human Protein Kinase C beta II Complexed with a Bisindolylmaleimide Inhibitor; Biochemistry, 45:13970-13981, 2006; PubMed: 17115692; DOI: 10.1021/bi061128h

実験手法

X-RAY DIFFRACTION (2.6 Å)