2HRM

Crystal structure of dUTPase complexed with substrate analogue methylene-dUTP

Summary for 2HRM

• Entry DOI: 10.2210/pdb2hrm/pdb
• Related: 2HR6
• Descriptor: Deoxyuridine 5'-triphosphate nucleotidohydrolase, 2'-DEOXY-5'-O-[(S)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]URIDINE, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: jelly roll, enzyme-substrate analogue ligand complex, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 16750.87

Authors

Barabas, O.,Kovari, J.,Tapai, R.,Vertessy, B.G. (deposition date: 2006-07-20, release date: 2007-07-31, Last modification date: 2023-08-30)

• Primary citation: Kovari, J.,Barabas, O.,Varga, B.,Bekesi, A.,Tolgyesi, F.,Fidy, J.,Nagy, J.,Vertessy, B.G.; Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site.; Proteins, 71:308-319, 2008; PubMed: 17932923; DOI: 10.1002/prot.21757

Experimental method

X-RAY DIFFRACTION (1.7 Å)