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2HRM

Crystal structure of dUTPase complexed with substrate analogue methylene-dUTP

Summary for 2HRM
Entry DOI10.2210/pdb2hrm/pdb
Related2HR6
DescriptorDeoxyuridine 5'-triphosphate nucleotidohydrolase, 2'-DEOXY-5'-O-[(S)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]URIDINE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsjelly roll, enzyme-substrate analogue ligand complex, hydrolase
Biological sourceEscherichia coli
Total number of polymer chains1
Total formula weight16750.87
Authors
Barabas, O.,Kovari, J.,Tapai, R.,Vertessy, B.G. (deposition date: 2006-07-20, release date: 2007-07-31, Last modification date: 2023-08-30)
Primary citationKovari, J.,Barabas, O.,Varga, B.,Bekesi, A.,Tolgyesi, F.,Fidy, J.,Nagy, J.,Vertessy, B.G.
Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site.
Proteins, 71:308-319, 2008
Cited by
PubMed: 17932923
DOI: 10.1002/prot.21757
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

221051

数据于2024-06-12公开中

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