2HR6
Crystal structure of dUTPase in complex with substrate analogue dUDP and manganese
Summary for 2HR6
Entry DOI | 10.2210/pdb2hr6/pdb |
Descriptor | Deoxyuridine 5'-triphosphate nucleotidohydrolase, MANGANESE (II) ION, DEOXYURIDINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | jelly roll, enzyme-ligand-metal complex, hydrolase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 16807.78 |
Authors | Barabas, O.,Kovari, J.,Tapai, R.,Vertessy, B.G. (deposition date: 2006-07-19, release date: 2007-07-31, Last modification date: 2023-08-30) |
Primary citation | Kovari, J.,Barabas, O.,Varga, B.,Bekesi, A.,Tolgyesi, F.,Fidy, J.,Nagy, J.,Vertessy, B.G. Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site. Proteins, 71:308-319, 2008 Cited by PubMed: 17932923DOI: 10.1002/prot.21757 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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