2HP4

Computational design and crystal structure of an enhanced affinity mutant human CD8-alpha-alpha co-receptor

2HP4 の概要

• エントリーDOI: 10.2210/pdb2hp4/pdb
• 分子名称: T-cell surface glycoprotein CD8 alpha chain, SULFATE ION, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: cd8, co-receptor, soluble protein, kd, protein engineering, immunotherapy, immune-suppressor, immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P01732
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 26537.72

構造登録者

Rizkallah, P.J.,Cole, D.K.,Jakobsen, B.K.,Boulter, J.M.,Glick, M.,Gao, G.F. (登録日: 2006-07-17, 公開日: 2007-02-06, 最終更新日: 2023-10-25)

• 主引用文献: Cole, D.K.,Rizkallah, P.J.,Boulter, J.M.,Sami, M.,Vuidepot, A.-L.,Glick, M.,Gao, F.,Bell, J.I.,Jakobsen, B.K.,Gao, G.F.; Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor; Proteins, 67:65-74, 2007; PubMed: 17243170; DOI: 10.1002/prot.21176

実験手法

X-RAY DIFFRACTION (2.1 Å)