2HM9

Solution structure of dihydrofolate reductase complexed with trimethoprim, 33 structures

Summary for 2HM9

Entry DOI	10.2210/pdb2hm9/pdb
Related	1AO8 1BZF 1LUD 1YHO 2L28 3DFR 3HQP
Descriptor	Dihydrofolate reductase, 2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM (2 entities in total)
Functional Keywords	oxidoreductase, dhfr, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Lactobacillus casei
Total number of polymer chains	1
Total formula weight	18622.92
Authors	Polshakov, V.I.,Birdsall, B. (deposition date: 2006-07-11, release date: 2007-06-05, Last modification date: 2011-07-13)
Primary citation	Feeney, J.,Birdsall, B.,Kovalevskaya, N.V.,Smurnyy, Y.D.,Navarro-Peran, E.M.,Polshakov, V.I. NMR structures of apo L.casei dihydrofolate reductase and its complexes with trimethoprim and NADPH. Contributions to positive cooperative binding from ligand-induced refolding, conformational changes and interligand hydrophobic interactions Biochemistry, 2011 Cited by PubMed: 21410224 DOI: 10.1021/bi200067t PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation