2HLE

Structural and biophysical characterization of the EPHB4-EPHRINB2 protein protein interaction and receptor specificity.

Summary for 2HLE

Related2BBA 1NUK 1KGY
DescriptorEphrin type-B receptor 4, Ephrin-B2 (3 entities in total)
Functional Keywordsprotein-protein interaction, receptor tryosine kinase, bi-directional cell signaling, transferase-transferase receptor complex, structural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d, transferase/transferase receptor
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein P54760 P52799
Total number of polymer chains2
Total molecular weight37141.29
Authors
Chrencik, J.E.,Brooun, A.,Kuhn, P.,Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) (deposition date: 2006-07-06, release date: 2006-08-22, Last modification date: 2011-07-13)
Primary citation
Chrencik, J.E.,Brooun, A.,Kraus, M.L.,Recht, M.I.,Kolatkar, A.R.,Han, G.W.,Seifert, J.M.,Widmer, H.,Auer, M.,Kuhn, P.
Structural and Biophysical Characterization of the EphB4-EphrinB2 Protein-Protein Interaction and Receptor Specificity.
J.Biol.Chem., 281:28185-28192, 2006
PubMed: 16867992 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M605766200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.05 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.293141.0%6.4%8.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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