2HFP

Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands

Summary for 2HFP

• Entry DOI: 10.2210/pdb2hfp/pdb
• Descriptor: Peroxisome proliferator-activated receptor gamma, SRC Peptide Fragment, 3-(4-METHOXYPHENYL)-N-(PHENYLSULFONYL)-1-[3-(TRIFLUOROMETHYL)BENZYL]-1H-INDOLE-2-CARBOXAMIDE, ... (4 entities in total)
• Functional Keywords: ppar ppargamma lbd, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q86U60
• Total number of polymer chains: 2
• Total formula weight: 36028.53

Authors

Pokross, M.E.,Evdokimov, A.G.,Walter, R.L.,Mekel, M.J.,Hopkins, C.R. (deposition date: 2006-06-25, release date: 2006-09-19, Last modification date: 2024-02-14)

• Primary citation: Hopkins, C.R.,O'neil, S.V.,Laufersweiler, M.C.,Wang, Y.,Pokross, M.,Mekel, M.,Evdokimov, A.,Walter, R.,Kontoyianni, M.,Petrey, M.E.,Sabatakos, G.,Roesgen, J.T.,Richardson, E.,Demuth Jr., T.P.; Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis.; Bioorg.Med.Chem.Lett., 16:5659-5663, 2006; PubMed: 16919947; DOI: 10.1016/j.bmcl.2006.08.003

Experimental method

X-RAY DIFFRACTION (2 Å)