2HE4

The crystal structure of the second PDZ domain of human NHERF-2 (SLC9A3R2) interacting with a mode 1 PDZ binding motif

Summary for 2HE4

Entry DOI	10.2210/pdb2he4/pdb
Descriptor	Na(+)/H(+) exchange regulatory cofactor NHE-RF2, 1,2-ETHANEDIOL (3 entities in total)
Functional Keywords	phosphorylation, structural genomics, structural genomics consortium, sgc, unknown function
Biological source	Homo sapiens (human)
Cellular location	Endomembrane system; Peripheral membrane protein: Q15599
Total number of polymer chains	1
Total formula weight	9993.38
Authors	Papagrigoriou, E.,Elkins, J.M.,Berridge, G.,Gileady, O.,Colebrook, S.,Gileadi, C.,Salah, E.,Savitsky, P.,Pantic, N.,Gorrec, F.,Bunkoczi, G.,Weigelt, J.,Arrowsmith, C.,Sundstrom, M.,Edwards, A.,Doyle, D.A.,Structural Genomics Consortium (SGC) (deposition date: 2006-06-21, release date: 2006-07-18, Last modification date: 2023-08-30)
Primary citation	Elkins, J.M.,Papagrigoriou, E.,Berridge, G.,Yang, X.,Phillips, C.,Gileadi, C.,Savitsky, P.,Doyle, D.A. Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions. Protein Sci., 16:683-694, 2007 Cited by PubMed: 17384233 DOI: 10.1110/ps.062657507 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation