2HE4

The crystal structure of the second PDZ domain of human NHERF-2 (SLC9A3R2) interacting with a mode 1 PDZ binding motif

2HE4 の概要

• エントリーDOI: 10.2210/pdb2he4/pdb
• 分子名称: Na(+)/H(+) exchange regulatory cofactor NHE-RF2, 1,2-ETHANEDIOL (3 entities in total)
• 機能のキーワード: phosphorylation, structural genomics, structural genomics consortium, sgc, unknown function
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endomembrane system; Peripheral membrane protein: Q15599
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9993.38

構造登録者

Papagrigoriou, E.,Elkins, J.M.,Berridge, G.,Gileady, O.,Colebrook, S.,Gileadi, C.,Salah, E.,Savitsky, P.,Pantic, N.,Gorrec, F.,Bunkoczi, G.,Weigelt, J.,Arrowsmith, C.,Sundstrom, M.,Edwards, A.,Doyle, D.A.,Structural Genomics Consortium (SGC) (登録日: 2006-06-21, 公開日: 2006-07-18, 最終更新日: 2023-08-30)

• 主引用文献: Elkins, J.M.,Papagrigoriou, E.,Berridge, G.,Yang, X.,Phillips, C.,Gileadi, C.,Savitsky, P.,Doyle, D.A.; Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.; Protein Sci., 16:683-694, 2007; PubMed: 17384233; DOI: 10.1110/ps.062657507

実験手法

X-RAY DIFFRACTION (1.45 Å)