2HCT

Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine NAAPD synthesis and hydrolysis activities

Summary for 2HCT

Entry DOI	10.2210/pdb2hct/pdb
Descriptor	ADP-ribosyl cyclase 1, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE (3 entities in total)
Functional Keywords	beta sheets, alpha bundle, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type II membrane protein: P28907
Total number of polymer chains	2
Total formula weight	61287.11
Authors	Liu, Q.,Kriksunov, I.A.,Hao, Q.,Graeff, R.,Lee, H.C. (deposition date: 2006-06-18, release date: 2006-08-22, Last modification date: 2023-08-30)
Primary citation	Graeff, R.,Liu, Q.,Kriksunov, I.A.,Hao, Q.,Lee, H.C. Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities. J.Biol.Chem., 281:28951-28957, 2006 Cited by PubMed: 16861223 DOI: 10.1074/jbc.M604370200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation