2HC2
Engineered protein tyrosine phosphatase beta catalytic domain
Summary for 2HC2
Entry DOI | 10.2210/pdb2hc2/pdb |
Descriptor | Receptor-type tyrosine-protein phosphatase beta, MAGNESIUM ION, SODIUM ION, ... (4 entities in total) |
Functional Keywords | protein tyrosine phosphatase, wpd-loop, sulfamic acid, phosphatase, inhibitor, drug design, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane ; Single-pass type I membrane protein : P23467 |
Total number of polymer chains | 1 |
Total formula weight | 33850.63 |
Authors | Evdokimov, A.G.,Pokross, M.,Walter, R.,Mekel, M. (deposition date: 2006-06-15, release date: 2006-06-27, Last modification date: 2023-08-30) |
Primary citation | Evdokimov, A.G.,Pokross, M.,Walter, R.,Mekel, M.,Cox, B.,Li, C.,Bechard, R.,Genbauffe, F.,Andrews, R.,Diven, C.,Howard, B.,Rastogi, V.,Gray, J.,Maier, M.,Peters, K.G. Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery. Acta Crystallogr.,Sect.D, 62:1435-1445, 2006 Cited by PubMed: 17139078DOI: 10.1107/S0907444906037784 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
Download full validation report