2HC2

Engineered protein tyrosine phosphatase beta catalytic domain

2HC2 の概要

• エントリーDOI: 10.2210/pdb2hc2/pdb
• 分子名称: Receptor-type tyrosine-protein phosphatase beta, MAGNESIUM ION, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: protein tyrosine phosphatase, wpd-loop, sulfamic acid, phosphatase, inhibitor, drug design, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane ; Single-pass type I membrane protein : P23467
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33850.63

構造登録者

Evdokimov, A.G.,Pokross, M.,Walter, R.,Mekel, M. (登録日: 2006-06-15, 公開日: 2006-06-27, 最終更新日: 2023-08-30)

• 主引用文献: Evdokimov, A.G.,Pokross, M.,Walter, R.,Mekel, M.,Cox, B.,Li, C.,Bechard, R.,Genbauffe, F.,Andrews, R.,Diven, C.,Howard, B.,Rastogi, V.,Gray, J.,Maier, M.,Peters, K.G.; Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.; Acta Crystallogr.,Sect.D, 62:1435-1445, 2006; PubMed: 17139078; DOI: 10.1107/S0907444906037784

実験手法

X-RAY DIFFRACTION (1.4 Å)