2H9I

Mycobacterium tuberculosis InhA bound with ETH-NAD adduct

Summary for 2H9I

• Entry DOI: 10.2210/pdb2h9i/pdb
• Related: 1ZID
• Descriptor: Enoyl-[acyl-carrier-protein] reductase [NADH], {(2R,3S,4R,5R)-5-[(4S)-3-(AMINOCARBONYL)-4-(2-ETHYLISONICOTINOYL)PYRIDIN-1(4H)-YL]-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL}METHYL [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE (3 entities in total)
• Functional Keywords: inha, ethionamide, eth, tuberculosis, oxidoreductase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 29192.15

Authors

Wang, F.,Sacchettini, J.C. (deposition date: 2006-06-09, release date: 2007-01-30, Last modification date: 2023-08-30)

• Primary citation: Wang, F.,Langley, R.,Gulten, G.,Dover, L.G.,Besra, G.S.,Jacobs, W.R.,Sacchettini, J.C.; Mechanism of thioamide drug action against tuberculosis and leprosy.; J.Exp.Med., 204:73-78, 2007; PubMed: 17227913; DOI: 10.1084/jem.20062100

Experimental method

X-RAY DIFFRACTION (2.2 Å)