2H42

Crystal structure of PDE5 in complex with sildenafil

Summary for 2H42

• Entry DOI: 10.2210/pdb2h42/pdb
• Related: 2H40 2H44
• Descriptor: cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: viagra, pde5, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 115058.46

Authors

Wang, H.,Ke, H. (deposition date: 2006-05-23, release date: 2006-06-06, Last modification date: 2023-08-30)

• Primary citation: Wang, H.,Liu, Y.,Huai, Q.,Cai, J.,Zoraghi, R.,Francis, S.H.,Corbin, J.D.,Robinson, H.,Xin, Z.,Lin, G.,Ke, H.; Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development; J.Biol.Chem., 281:21469-21479, 2006; PubMed: 16735511; DOI: 10.1074/jbc.M512527200

Experimental method

X-RAY DIFFRACTION (2.3 Å)