2H0T
Crystal structure of the M69V E166A double mutant of SHV-1 b-lactamase complexed to clavulanic acid
Summary for 2H0T
| Entry DOI | 10.2210/pdb2h0t/pdb |
| Related | 1RCJ 2A34 2A49 |
| Descriptor | Broad-spectrum beta-lactamase SHV-1, N-(2-HYDROXY-4-OXO-BUTYL)-N-(3-OXO-TRANSPROPENYL)AMINE, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... (5 entities in total) |
| Functional Keywords | antibiotic resistance, b-lactamase inhibitor, hydrolase |
| Biological source | Klebsiella pneumoniae |
| Total number of polymer chains | 1 |
| Total formula weight | 30229.59 |
| Authors | van den Akker, F.,Padayatti, P.S. (deposition date: 2006-05-15, release date: 2007-01-30, Last modification date: 2023-08-30) |
| Primary citation | Totir, M.A.,Padayatti, P.S.,Helfand, M.S.,Carey, M.P.,Bonomo, R.A.,Carey, P.R.,van den Akker, F. Effect of the inhibitor-resistant M69V substitution on the structures and populations of trans-enamine beta-lactamase intermediates. Biochemistry, 45:11895-11904, 2006 Cited by PubMed: 17002290DOI: 10.1021/bi060990m PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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