2H0T
Crystal structure of the M69V E166A double mutant of SHV-1 b-lactamase complexed to clavulanic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Broad-spectrum beta-lactamase SHV-1 | polymer | 265 | 28816.9 | 1 | UniProt (Q5PSW7) Pfam (PF00144) Pfam (PF13354) UniProt (by SIFTS) (P0AD64) In PDB | Klebsiella pneumoniae | Extended-spectrum beta-lactamase SHV-11, SHV type extended spectrum beta-lactamase, Bla-SHV type 1 |
| 2 | A | N-(2-HYDROXY-4-OXO-BUTYL)-N-(3-OXO-TRANSPROPENYL)AMINE | non-polymer | 157.2 | 1 | Chemie (TEM) | |||
| 3 | A | CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | non-polymer | 508.6 | 2 | Chemie (MA4) | |||
| 4 | A | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 5 | water | water | 18.0 | 269 | Chemie (HOH) |
Sequence modifications
A: 26 - 290 (UniProt: Q5PSW7)
| PDB | External Database | Details |
|---|---|---|
| Val 69 | Met 65 | engineered mutation |
| Ala 166 | Glu 162 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28816.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1412.7 | |
| All* | Total formula weight | 30229.6 |
