2GZL

Structure of 2C-methyl-D-erythritol 2,4-clycodiphosphate synthase complexed with a CDP derived fluorescent inhibitor

Replaces:  2AO4

Summary for 2GZL

• Entry DOI: 10.2210/pdb2gzl/pdb
• Related: 1GX1 1KNJ 1U3P 2AMT
• Descriptor: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, 5'-O-{[({[2-({[5-(DIMETHYLAMINO)NAPHTHALEN-1-YL]SULFONYL}AMINO)ETHYL]OXY}PHOSPHINATO)OXY]PHOSPHINATO}CYT, ... (5 entities in total)
• Functional Keywords: isoprenoid, lyase, isoprene biosynthesis
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 17991.67

Authors

Crane, C.M.,Kaiser, J.,Ramsden, N.L.,Lauw, S.,Rohdich, F.,Wolfgang, E.,Hunter, W.N.,Bacher, A.,Diederich, F. (deposition date: 2006-05-11, release date: 2006-11-14, Last modification date: 2023-08-30)

• Primary citation: Crane, C.M.,Kaiser, J.,Ramsden, N.L.,Lauw, S.,Rohdich, F.,Eisenreich, W.,Hunter, W.N.,Bacher, A.,Diederich, F.; Fluorescent Inhibitors for Ispf, an Enzyme in the Non-Mevalonate Pathway for Isoprenoid Biosynthesis and a Potential Target for Antimalarial Therapy.; Angew.Chem.Int.Ed.Engl., 45:1069-1074, 2006; PubMed: 16392111; DOI: 10.1002/anie.200503003

Experimental method

X-RAY DIFFRACTION (2.5 Å)