2GYS

2.7 A structure of the extracellular domains of the human beta common receptor involved in IL-3, IL-5, and GM-CSF signalling

Summary for 2GYS

• Entry DOI: 10.2210/pdb2gys/pdb
• Related: 1gh7
• Descriptor: Cytokine receptor common beta chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: dimer of interlocking chains of fibronectin-iii domains, four fibronectin-iii domains per chain, signaling protein, cytokine
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 98231.39

Authors

Carr, P.D.,Conlan, F.,Ford, S.,Ollis, D.L.,Young, I.G. (deposition date: 2006-05-09, release date: 2006-06-20, Last modification date: 2024-10-30)

Primary citation

Carr, P.D.,Conlan, F.,Ford, S.,Ollis, D.L.,Young, I.G.
An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope.
Acta Crystallogr.,Sect.F, 62:509-513, 2006

PubMed Abstract: X-ray diffraction has been used to produce and refine a model of the extracellular domains of the beta common cytokine receptor. A minor improvement in resolution has resulted in improved electron-density maps, which have given a clearer indication of the position and stabilization of the key residues Tyr15, Phe79, Tyr347, His349, Ile350 and Tyr403 in the elbow region between domain 1 and domain 4 of the dimer-related molecule.

PubMed: 16754968
DOI: 10.1107/S1744309106016812

Experimental method

X-RAY DIFFRACTION (2.7 Å)