2GV6

Crystal Structure of Matriptase with Inhibitor CJ-730

Summary for 2GV6

Entry DOI	10.2210/pdb2gv6/pdb
Related	2GV7
Descriptor	Suppressor of tumorigenicity 14, (S)-3-(3-(4-(2-GUANIDINOETHYL)PIPERIDIN-1-YL)-2-(NAPHTHALENE-2-SULFONAMIDO)-3-OXOPROPYL)BENZIMIDAMIDE (3 entities in total)
Functional Keywords	matriptase, inhibitor, complex structure, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type II membrane protein (Probable): Q9Y5Y6
Total number of polymer chains	1
Total formula weight	27013.44
Authors	Bode, W. (deposition date: 2006-05-02, release date: 2006-06-06, Last modification date: 2021-06-23)
Primary citation	Steinmetzer, T.,Schweinitz, A.,Sturzebecher, A.,Donnecke, D.,Uhland, K.,Schuster, O.,Steinmetzer, P.,Muller, F.,Friedrich, R.,Than, M.E.,Bode, W.,Sturzebecher, J. Secondary Amides of Sulfonylated 3-Amidinophenylalanine. New Potent and Selective Inhibitors of Matriptase. J.Med.Chem., 49:4116-4126, 2006 Cited by PubMed: 16821772 DOI: 10.1021/jm051272l PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation