2GV7

Structure of Matriptase in Complex with Inhibitor CJ-672

Summary for 2GV7

Related2GV6
DescriptorSuppressor of tumorigenicity 14, (S)-4-(4-(3-(3-CARBAMIMIDOYLPHENYL)-2-(2,4,6-TRIISOPROPYLPHENYLSULFONAMIDO)PROPANOYL)PIPERAZINE-1-CARBONYL)PIPERIDINE-1-CARBOXIMIDAMIDE (3 entities in total)
Functional Keywordsmatriptase, inhibitor, complex structure, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type II membrane protein (Probable) Q9Y5Y6
Total number of polymer chains1
Total molecular weight27158.69
Authors
Bode, W. (deposition date: 2006-05-02, release date: 2006-06-06, Last modification date: 2011-07-13)
Primary citation
Steinmetzer, T.,Schweinitz, A.,Sturzebecher, A.,Donnecke, D.,Uhland, K.,Schuster, O.,Steinmetzer, P.,Muller, F.,Friedrich, R.,Than, M.E.,Bode, W.,Sturzebecher, J.
Secondary Amides of Sulfonylated 3-Amidinophenylalanine. New Potent and Selective Inhibitors of Matriptase.
J.Med.Chem., 49:4116-4126, 2006
PubMed: 16821772 (PDB entries with the same primary citation)
DOI: 10.1021/jm051272l
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers1001.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report