2GU8

Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies

2GU8 の概要

• エントリーDOI: 10.2210/pdb2gu8/pdb
• 分子名称: CAMP-dependent protein kinase, alpha-catalytic subunit, inhibitor of CAMP-dependent protein kinase, N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE, ... (4 entities in total)
• 機能のキーワード: camp-dependent protein kinase, pka, akt, kinase, drug design, ternary complex, signaling protein, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): P17612
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42076.76

構造登録者

Murray, J.M. (登録日: 2006-04-28, 公開日: 2007-05-01, 最終更新日: 2011-07-13)

• 主引用文献: Lin, X.,Murray, J.M.,Rico, A.C.,Wang, M.X.,Chu, D.T.,Zhou, Y.,Del Rosario, M.,Kaufman, S.,Ma, S.,Fang, E.,Crawford, K.,Jefferson, A.B.; Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies; Bioorg.Med.Chem.Lett., 16:4163-4168, 2006; PubMed: 16765046; DOI: 10.1016/j.bmcl.2006.05.092

実験手法

X-RAY DIFFRACTION (2.2 Å)