2GRU

Crystal structure of 2-deoxy-scyllo-inosose synthase complexed with carbaglucose-6-phosphate, NAD+ and Co2+

Summary for 2GRU

Entry DOI	10.2210/pdb2gru/pdb
Descriptor	2-deoxy-scyllo-inosose synthase, COBALT (II) ION, SULFITE ION, ... (9 entities in total)
Functional Keywords	aminoglycoside, 2-deoxystreptamine, dehydroquinate synthase, lyase
Biological source	Bacillus circulans
Total number of polymer chains	2
Total formula weight	83940.13
Authors	Nango, E.,Kumasaka, T. (deposition date: 2006-04-25, release date: 2007-05-08, Last modification date: 2023-10-25)
Primary citation	Nango, E.,Kumasaka, T.,Hirayama, T.,Tanaka, N.,Eguchi, T. Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD+ Proteins, 70:517-527, 2008 Cited by PubMed: 17879343 DOI: 10.1002/prot.21526 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation