2GNI

PKA fivefold mutant model of Rho-kinase with inhibitor Fasudil (HA1077)

Summary for 2GNI

• Entry DOI: 10.2210/pdb2gni/pdb
• Related: 1Q8T 1Q8U 1Q8W 2GNF 2GNG 2GNH 2GNJ 2GNL
• Descriptor: cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor alpha, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, ... (4 entities in total)
• Functional Keywords: pka, mutant, rho-kinase, surrogate, inhibitor, fasudil, ha1077, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Bos taurus (cattle); More
• Cellular location: Cytoplasm: P00517
• Total number of polymer chains: 2
• Total formula weight: 43293.24

Authors

Bonn, S.,Herrero, S.,Breitenlechner, C.B.,Engh, R.A.,Gassel, M.,Bossemeyer, D. (deposition date: 2006-04-10, release date: 2006-05-23, Last modification date: 2024-04-03)

• Primary citation: Bonn, S.,Herrero, S.,Breitenlechner, C.B.,Erlbruch, A.,Lehmann, W.,Engh, R.A.,Gassel, M.,Bossemeyer, D.; Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity; J.Biol.Chem., 281:24818-24830, 2006; PubMed: 16699172; DOI: 10.1074/jbc.M512374200

Experimental method

X-RAY DIFFRACTION (2.27 Å)