2GKE

Crystal structure of diaminopimelate epimerase in complex with an irreversible inhibitor LL-AziDAP

Summary for 2GKE

Entry DOI	10.2210/pdb2gke/pdb
Related	2GKJ
Descriptor	Diaminopimelate epimerase, (2S,6S)-2,6-DIAMINO-2-METHYLHEPTANEDIOIC ACID, GLYCEROL, ... (5 entities in total)
Functional Keywords	enzyme-inhibitor complex, covalently bound inhibitor, isomerase
Biological source	Haemophilus influenzae
Cellular location	Cytoplasm: P44859
Total number of polymer chains	1
Total formula weight	30755.95
Authors	Pillai, B.,Cherney, M.M.,Diaper, C.M.,Sutherland, A.,Blanchard, J.S.,Vederas, J.C.,James, M.N. (deposition date: 2006-04-01, release date: 2006-05-16, Last modification date: 2011-07-13)
Primary citation	Pillai, B.,Cherney, M.M.,Diaper, C.M.,Sutherland, A.,Blanchard, J.S.,Vederas, J.C.,James, M.N. Structural insights into stereochemical inversion by diaminopimelate epimerase: An antibacterial drug target. Proc.Natl.Acad.Sci.Usa, 103:8668-8673, 2006 Cited by PubMed: 16723397 DOI: 10.1073/pnas.0602537103 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation