2GK1

X-ray crystal structure of NGT-bound HexA

Summary for 2GK1

• Entry DOI: 10.2210/pdb2gk1/pdb
• Related: 2GJX
• Descriptor: Beta-hexosaminidase subunit alpha, Beta-hexosaminidase subunit beta, Beta-hexosaminidase subunit beta chain B, ... (9 entities in total)
• Functional Keywords: beta-hexoasaminidase a, glycosidase, tay-sachs disease, sandhoff disease, nag-thazoline, gm2 gangliodosis, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 20
• Total formula weight: 455559.71

Authors

Lemieux, M.J.,Mark, B.L.,Cherney, M.M.,Withers, S.G.,Mahuran, D.J.,James, M.N. (deposition date: 2006-03-31, release date: 2006-05-30, Last modification date: 2020-07-29)

• Primary citation: Lemieux, M.J.,Mark, B.L.,Cherney, M.M.,Withers, S.G.,Mahuran, D.J.,James, M.N.; Crystallographic Structure of Human beta-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of G(M2) Ganglioside Hydrolysis.; J.Mol.Biol., 359:913-929, 2006; PubMed: 16698036; DOI: 10.1016/j.jmb.2006.04.004

Experimental method

X-RAY DIFFRACTION (3.25 Å)