2GK1
X-ray crystal structure of NGT-bound HexA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F, K, P (A, C, E, G) | Beta-hexosaminidase subunit alpha | polymer | 52 | 6210.8 | 4 | UniProt (P06865) Pfam (PF14845) | Homo sapiens (Human) | Beta-N-acetylhexosaminidase subunit alpha,Hexosaminidase subunit A,N-acetyl-beta-glucosaminidase subunit alpha |
| 2 | B, G, L, Q (I, J, K, L) | Beta-hexosaminidase subunit alpha | polymer | 440 | 50495.0 | 4 | UniProt (P06865) Pfam (PF14845) Pfam (PF00728) | Homo sapiens (Human) | Beta-N-acetylhexosaminidase subunit alpha,Hexosaminidase subunit A,N-acetyl-beta-glucosaminidase subunit alpha |
| 3 | C, H, M, R (B, D, F, H) | Beta-hexosaminidase subunit beta | polymer | 58 | 6416.4 | 4 | UniProt (P07686) Pfam (PF14845) | Homo sapiens (Human) | Beta-N-acetylhexosaminidase subunit beta,Hexosaminidase subunit B,Cervical cancer proto-oncogene 7 protein,HCC-7,N-acetyl-beta-glucosaminidase subunit beta |
| 4 | D, I, N, S (M, O, Q, S) | Beta-hexosaminidase subunit beta chain B | polymer | 190 | 21653.6 | 4 | UniProt (P07686) Pfam (PF14845) Pfam (PF00728) | Homo sapiens (Human) | Beta-N-acetylhexosaminidase subunit beta,Hexosaminidase subunit B,Cervical cancer proto-oncogene 7 protein,HCC-7,N-acetyl-beta-glucosaminidase subunit beta |
| 5 | E, J, O, T (N, P, R, T) | Beta-hexosaminidase subunit beta chain A | polymer | 237 | 27305.9 | 4 | UniProt (P07686) Pfam (PF00728) | Homo sapiens (Human) | Beta-N-acetylhexosaminidase subunit beta,Hexosaminidase subunit B,Cervical cancer proto-oncogene 7 protein,HCC-7,N-acetyl-beta-glucosaminidase subunit beta |
| 6 | DA, U, V, W, Y (d, U, V, W, Y) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 5 | In PDB GlyTouCan (G15407YE) | |||
| 7 | AA, BA, CA, EA, X... (a, b, c, e, X...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
| 8 | FA, GA, HA, IA, JA... (A, B, C, D, E...) | 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL | non-polymer | 219.3 | 8 | Chemie (NGT) | |||
| 9 | NA, OA, PA, QA (A, B, C, D) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
I, J, K, L: 89 - 528 (UniProt: P06865)
| PDB | External Database | Details |
|---|---|---|
| Val 436 | Ile 436 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 20 |
| Total formula weight | 448326.5 | |
| Branched | Number of molecules | 11 |
| Total formula weight | 5479.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1754.1 | |
| All* | Total formula weight | 455559.7 |
