2GK1
X-ray crystal structure of NGT-bound HexA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F, K, P (A, C, E, G) | Beta-hexosaminidase subunit alpha | polymer | 52 | 6210.8 | 4 | UniProt (P06865) Pfam (PF14845) | Homo sapiens (Human) | Beta-N-acetylhexosaminidase subunit alpha,Hexosaminidase subunit A,N-acetyl-beta-glucosaminidase subunit alpha |
| 2 | B, G, L, Q (I, J, K, L) | Beta-hexosaminidase subunit alpha | polymer | 440 | 50495.0 | 4 | UniProt (P06865) Pfam (PF14845) Pfam (PF00728) | Homo sapiens (Human) | Beta-N-acetylhexosaminidase subunit alpha,Hexosaminidase subunit A,N-acetyl-beta-glucosaminidase subunit alpha |
| 3 | C, H, M, R (B, D, F, H) | Beta-hexosaminidase subunit beta | polymer | 58 | 6416.4 | 4 | UniProt (P07686) Pfam (PF14845) | Homo sapiens (Human) | Beta-N-acetylhexosaminidase subunit beta,Hexosaminidase subunit B,Cervical cancer proto-oncogene 7 protein,HCC-7,N-acetyl-beta-glucosaminidase subunit beta |
| 4 | D, I, N, S (M, O, Q, S) | Beta-hexosaminidase subunit beta chain B | polymer | 190 | 21653.6 | 4 | UniProt (P07686) Pfam (PF14845) Pfam (PF00728) | Homo sapiens (Human) | Beta-N-acetylhexosaminidase subunit beta,Hexosaminidase subunit B,Cervical cancer proto-oncogene 7 protein,HCC-7,N-acetyl-beta-glucosaminidase subunit beta |
| 5 | E, J, O, T (N, P, R, T) | Beta-hexosaminidase subunit beta chain A | polymer | 237 | 27305.9 | 4 | UniProt (P07686) Pfam (PF00728) | Homo sapiens (Human) | Beta-N-acetylhexosaminidase subunit beta,Hexosaminidase subunit B,Cervical cancer proto-oncogene 7 protein,HCC-7,N-acetyl-beta-glucosaminidase subunit beta |
| 6 | DA, U, V, W, Y (d, U, V, W, Y) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 5 | In PDB GlyTouCan (G15407YE) | |||
| 7 | AA, BA, CA, EA, X... (a, b, c, e, X...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
| 8 | FA, GA, HA, IA, JA... (A, B, C, D, E...) | 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL | non-polymer | 219.3 | 8 | Chemie (NGT) PubChem (4340) PubChem (71206603) PubChem (44451348) PubChem (46936781) PubChem (71210472) PubChem (71210520) PubChem (58834157) PubChem (68347933) PubChem (68347960) PubChem (71052256) PubChem (86316265) PubChem (86316266) PubChem (5289024) PubChem (101088187) PubChem (101353454) PubChem (101433794) PubChem (118375127) PubChem (10398518) PubChem (10867771) PubChem (11252967) PubChem (154437974) PubChem (126968685) PubChem (133655659) PubChem (143636894) PubChem (157893773) | |||
| 9 | NA, OA, PA, QA (A, B, C, D) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
I, J, K, L: 89 - 528 (UniProt: P06865)
| PDB | External Database | Details |
|---|---|---|
| Val 436 | Ile 436 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 20 |
| Total formula weight | 448326.5 | |
| Branched | Number of molecules | 11 |
| Total formula weight | 5479.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1754.1 | |
| All* | Total formula weight | 455559.7 |
