2GGV

Crystal structure of the West Nile virus NS2B-NS3 protease, His51Ala mutant

Summary for 2GGV

Entry DOI	10.2210/pdb2ggv/pdb
Descriptor	non-structural protein 2B, non-structural protein 3 (3 entities in total)
Functional Keywords	beta barrel, serine protease, viral protease, flavivirus, hydrolase
Biological source	West Nile virus More
Cellular location	Envelope protein E: Virion membrane; Multi- pass membrane protein: Q203W3 Q203W3
Total number of polymer chains	2
Total formula weight	26016.94
Authors	Aleshin, A.E.,Shiryaev, S.A.,Strongin, A.Y.,Liddington, R.C. (deposition date: 2006-03-24, release date: 2007-03-27, Last modification date: 2024-02-14)
Primary citation	Aleshin, A.E.,Shiryaev, S.A.,Strongin, A.Y.,Liddington, R.C. Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold. Protein Sci., 16:795-806, 2007 Cited by PubMed: 17400917 DOI: 10.1110/ps.072753207 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation