2GDO

4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors

Summary for 2GDO

• Entry DOI: 10.2210/pdb2gdo/pdb
• Descriptor: Serine/threonine-protein kinase Chk1, SULFATE ION, 4-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YLAMINO]-3-(1H-BENZIMIDAZOL-2-YL)-6-CHLOROQUINOLIN-2(1H)-ONE, ... (4 entities in total)
• Functional Keywords: drug design, atp-binding, cell cycle, dna damage, serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: O14757
• Total number of polymer chains: 1
• Total formula weight: 34483.89

Authors

Le, V.,Dove, J.,Fang, E.,Bussiere, D.E. (deposition date: 2006-03-16, release date: 2007-03-20, Last modification date: 2024-02-14)

Primary citation

Ni, Z.J.,Barsanti, P.,Brammeier, N.,Diebes, A.,Poon, D.J.,Ng, S.,Pecchi, S.,Pfister, K.,Renhowe, P.A.,Ramurthy, S.,Wagman, A.S.,Bussiere, D.E.,Le, V.,Zhou, Y.,Jansen, J.M.,Ma, S.,Gesner, T.G.
4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors.
Bioorg.Med.Chem.Lett., 16:3121-3124, 2006

PubMed Abstract: CHK-1 is one of the key enzymes regulating checkpoints in cellular growth cycles. Novel 4-(amino-alkylamino)-3-benzimidazole-quinolinones were prepared and assayed for their ability to inhibit CHK-1. These compounds are potent cell permeable CHK-1 inhibitors and showed synergistic effect with a DNA-damaging agent, camptothecin.

PubMed: 16603354
DOI: 10.1016/j.bmcl.2006.03.059

Experimental method

X-RAY DIFFRACTION (3 Å)