2GDO

4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine/threonine-protein kinase Chk1	polymer	295	33871.9	1	UniProt (O14757) Pfam (PF00069) In PDB	Homo sapiens (human)
2	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	A	4-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YLAMINO]-3-(1H-BENZIMIDAZOL-2-YL)-6-CHLOROQUINOLIN-2(1H)-ONE	non-polymer		419.9	1	Chemie (12C)
4		water	water		18.0	184	Chemie (HOH)

Sequence modifications

A: 1 - 289 (UniProt: O14757)

PDB	External Database	Details
His 290	-	expression tag
His 291	-	expression tag
His 292	-	expression tag
His 293	-	expression tag
His 294	-	expression tag
His 295	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33871.9
Non-Polymers*	Number of molecules	3
	Total formula weight	612.0
All*	Total formula weight	34483.9

*Water molecules are not included.