2G8N
Structure of hPNMT with inhibitor 3-Hydroxymethyl-7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy
Summary for 2G8N
Entry DOI | 10.2210/pdb2g8n/pdb |
Related | 1HNN 1N7J 1NJI 1YZ3 2AN3 2AN4 |
Descriptor | Phenylethanolamine N-methyltransferase, (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total) |
Functional Keywords | methyltransferase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 65166.43 |
Authors | Drinkwater, N.,Gee, C.L.,Martin, J.L. (deposition date: 2006-03-02, release date: 2006-09-12, Last modification date: 2023-10-25) |
Primary citation | Grunewald, G.L.,Seim, M.R.,Regier, R.C.,Martin, J.L.,Gee, C.L.,Drinkwater, N.,Criscione, K.R. Comparison of the Binding of 3-Fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with Their Isosteric Sulfonamides to the Active Site of Phenylethanolamine N-Methyltransferase J.Med.Chem., 49:5424-5433, 2006 Cited by PubMed: 16942016DOI: 10.1021/jm060466d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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