2G70
Structure of human PNMT in complex with inhibitor 3-hydroxymethyl-7-nitro-THIQ and AdoMet (SAM)
Summary for 2G70
Entry DOI | 10.2210/pdb2g70/pdb |
Related | 1HNN 1N7J 1NJI 1YZ3 2AN3 2AN4 2g71 2g72 |
Descriptor | Phenylethanolamine N-methyltransferase, S-ADENOSYLMETHIONINE, [(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL, ... (5 entities in total) |
Functional Keywords | methyltransferase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 65208.42 |
Authors | Tyndall, J.D.A.,Gee, C.L.,Martin, J.L. (deposition date: 2006-02-27, release date: 2007-02-13, Last modification date: 2023-10-25) |
Primary citation | Gee, C.L.,Drinkwater, N.,Tyndall, J.D.A.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L. Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase J.Med.Chem., 50:4845-4853, 2007 Cited by PubMed: 17845018DOI: 10.1021/jm0703385 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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