2G70
Structure of human PNMT in complex with inhibitor 3-hydroxymethyl-7-nitro-THIQ and AdoMet (SAM)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Phenylethanolamine N-methyltransferase | polymer | 289 | 31846.0 | 2 | UniProt (P11086) Pfam (PF01234) | Homo sapiens (human) | PNMTase, Noradrenaline N-methyltransferase |
| 2 | C, G (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (9865603) PubChem (12312798) PubChem (58766358) PubChem (87224684) PubChem (131697735) PubChem (145712080) PubChem (58633578) PubChem (60038769) PubChem (73897310) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) | |||
| 3 | D, E, H (A, B) | [(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL | non-polymer | 208.2 | 3 | Chemie (HNT) PubChem (10608431) PubChem (10822243) PubChem (21584368) | |||
| 4 | F (B) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) PubChem (1061) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 282 (UniProt: P11086)
| PDB | External Database | Details |
|---|---|---|
| Glu 283 | - | expression tag |
| His 284 | - | expression tag |
| His 285 | - | expression tag |
| His 286 | - | expression tag |
| His 287 | - | expression tag |
| His 288 | - | expression tag |
| His 289 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63691.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1516.5 | |
| All* | Total formula weight | 65208.4 |
