2G70
Structure of human PNMT in complex with inhibitor 3-hydroxymethyl-7-nitro-THIQ and AdoMet (SAM)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Phenylethanolamine N-methyltransferase | polymer | 289 | 31846.0 | 2 | UniProt (P11086) Pfam (PF01234) | Homo sapiens (human) | PNMTase, Noradrenaline N-methyltransferase |
| 2 | C, G (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) | |||
| 3 | D, E, H (A, B) | [(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL | non-polymer | 208.2 | 3 | Chemie (HNT) | |||
| 4 | F (B) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 282 (UniProt: P11086)
| PDB | External Database | Details |
|---|---|---|
| Glu 283 | - | expression tag |
| His 284 | - | expression tag |
| His 285 | - | expression tag |
| His 286 | - | expression tag |
| His 287 | - | expression tag |
| His 288 | - | expression tag |
| His 289 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63691.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1516.5 | |
| All* | Total formula weight | 65208.4 |
