2G5R

Crystal structure of Siglec-7 in complex with methyl-9-(aminooxalyl-amino)-9-deoxyNeu5Ac (oxamido-Neu5Ac)

Summary for 2G5R

Entry DOI	10.2210/pdb2g5r/pdb
Descriptor	Sialic acid-binding Ig-like lectin 7, 2-acetamido-2-deoxy-beta-D-glucopyranose, methyl 5-acetamido-9-{[amino(oxo)acetyl]amino}-3,5,9-trideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosidonic acid, ... (5 entities in total)
Functional Keywords	siglec, sialic acid, sialoside, cell adhesion
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: Q9Y286
Total number of polymer chains	1
Total formula weight	15391.00
Authors	Attrill, H.,Crocker, P.R.,van Aalten, D.M. (deposition date: 2006-02-23, release date: 2006-06-20, Last modification date: 2023-11-15)
Primary citation	Attrill, H.,Takazawa, H.,Witt, S.,Kelm, S.,Isecke, R.,Brossmer, R.,Ando, T.,Ishida, H.,Kiso, M.,Crocker, P.R.,van Aalten, D.M. The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design. Biochem.J., 397:271-278, 2006 Cited by PubMed: 16623661 DOI: 10.1042/BJ20060103 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation