2G48
crystal structure of human insulin-degrading enzyme in complex with amylin
Summary for 2G48
| Entry DOI | 10.2210/pdb2g48/pdb |
| Related | 2G47 2G49 2G54 2G56 |
| Descriptor | Insulin-degrading enzyme, Islet amyloid polypeptide, 1,4-DIETHYLENE DIOXIDE, ... (4 entities in total) |
| Functional Keywords | protein-peptide complex, hydrolase |
| Biological source | Homo sapiens (human) More |
| Cellular location | Secreted: P10997 |
| Total number of polymer chains | 4 |
| Total formula weight | 237425.10 |
| Authors | Shen, Y.,Tang, W.-J. (deposition date: 2006-02-21, release date: 2006-10-24, Last modification date: 2024-02-14) |
| Primary citation | Shen, Y.,Joachimiak, A.,Rosner, M.R.,Tang, W.J. Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature, 443:870-874, 2006 Cited by PubMed: 17051221DOI: 10.1038/nature05143 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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