2G1Q
crystal structure of KSP in complex with inhibitor 9h
Summary for 2G1Q
Entry DOI | 10.2210/pdb2g1q/pdb |
Descriptor | Kinesin-like protein KIF11, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | ksp, ksp-inhibitor complex, cell cycle |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P52732 |
Total number of polymer chains | 2 |
Total formula weight | 83787.05 |
Authors | |
Primary citation | Cox, C.D.,Torrent, M.,Breslin, M.J.,Mariano, B.J.,Whitman, D.B.,Coleman, P.J.,Buser, C.A.,Walsh, E.S.,Hamilton, K.,Schaber, M.D.,Lobell, R.B.,Tao, W.,South, V.J.,Kohl, N.E.,Yan, Y.,Kuo, L.C.,Prueksaritanont, T.,Slaughter, D.E.,Li, C.,Mahan, E.,Lu, B.,Hartman, G.D. Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP. Bioorg.Med.Chem.Lett., 16:3175-3179, 2006 Cited by PubMed: 16603356DOI: 10.1016/j.bmcl.2006.03.040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
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