2FO0
Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase
Summary for 2FO0
Entry DOI | 10.2210/pdb2fo0/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase ABL1 (1B ISOFORM), MYRISTIC ACID, 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, ... (5 entities in total) |
Functional Keywords | n-terminal cap, autoinhibition, myristoylation, sh3-sh2 clamp, phosphoserine, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 57292.21 |
Authors | Nagar, B.,Hantschel, O.,Seeliger, M.,Davies, J.M.,Weis, W.I.,Superti-Furga, G.,Kuriyan, J. (deposition date: 2006-01-12, release date: 2006-03-21, Last modification date: 2023-08-30) |
Primary citation | Nagar, B.,Hantschel, O.,Seeliger, M.,Davies, J.M.,Weis, W.I.,Superti-Furga, G.,Kuriyan, J. Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase. Mol.Cell, 21:787-798, 2006 Cited by PubMed: 16543148DOI: 10.1016/j.molcel.2006.01.035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
Download full validation report