2FM2
HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211
Summary for 2FM2
Entry DOI | 10.2210/pdb2fm2/pdb |
Related | 1A1R 1N1L 1RTL |
Descriptor | NS3 protease/helicase, NS4a protein, ZINC ION, ... (6 entities in total) |
Functional Keywords | hepatitis c virus, hcv, ns3/4a protease, ketoamide inhibitor, hydrolase |
Biological source | Hepatitis C virus More |
Total number of polymer chains | 4 |
Total formula weight | 48188.37 |
Authors | Yi, M.,Tong, X.,Skelton, A.,Chase, R.,Chen, T.,Prongay, A.,Bogen, S.L.,Saksena, A.K.,Njoroge, F.G.,Veselenak, R.L.,Pyles, R.B.,Bourne, N.,Malcolm, B.A.,Lemon, S.M. (deposition date: 2006-01-06, release date: 2006-02-07, Last modification date: 2024-04-03) |
Primary citation | Yi, M.,Tong, X.,Skelton, A.,Chase, R.,Chen, T.,Prongay, A.,Bogen, S.L.,Saksena, A.K.,Njoroge, F.G.,Veselenak, R.L.,Pyles, R.B.,Bourne, N.,Malcolm, B.A.,Lemon, S.M. Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations J.Biol.Chem., 281:8205-8215, 2006 Cited by PubMed: 16352601DOI: 10.1074/jbc.M510246200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report