1RTL
CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN: NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND PYRROLIDINE-5,5-TRANSLACTAM INHIBITOR
Summary for 1RTL
Entry DOI | 10.2210/pdb1rtl/pdb |
Related | 1N1L |
Descriptor | NS3 protease/helicase, NS4A COFACTOR, ZINC ION, ... (5 entities in total) |
Functional Keywords | viral protein, serine protease, nonstructural protein, cofactor peptide, helicase, inhibitor, translactam, viral protein complex |
Biological source | Hepatitis C virus More |
Total number of polymer chains | 4 |
Total formula weight | 47891.98 |
Authors | Skarzynski, T.,Somers, D.O.N. (deposition date: 2003-12-10, release date: 2004-12-14, Last modification date: 2021-10-27) |
Primary citation | Slater, M.J.,Amphlett, E.M.,Andrews, D.M.,Bamborough, P.,Carey, S.J.,Johnson, M.R.,Jones, P.S.,Mills, G.,Parry, N.R.,Somers, D.O.,Stewart, A.J.,Skarzynski, T. Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease Org.Lett., 5:4627-4630, 2003 Cited by PubMed: 14627400DOI: 10.1021/ol035826v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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