2FM0

Crystal structure of PDE4D in complex with L-869298

Summary for 2FM0

• Entry DOI: 10.2210/pdb2fm0/pdb
• Related: 2FM5
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: pde. enantiomer binding, inhibitor selectivity, camp signalling, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): Q08499
• Total number of polymer chains: 4
• Total formula weight: 168736.21

Authors

Huai, Q.,Sun, Y.,Wang, H.,Macdonald, D.,Aspiotis, R.,Robinson, H.,Huang, Z.,Ke, H. (deposition date: 2006-01-06, release date: 2006-03-28, Last modification date: 2024-04-03)

• Primary citation: Huai, Q.,Sun, Y.,Wang, H.,Macdonald, D.,Aspiotis, R.,Robinson, H.,Huang, Z.,Ke, H.; Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase; J.Med.Chem., 49:1867-1873, 2006; PubMed: 16539372; DOI: 10.1021/jm051273d

Experimental method

X-RAY DIFFRACTION (2 Å)