2FL2

crystal structure of KSP in complex with inhibitor 19

Summary for 2FL2

Related2FKY 2FL6
DescriptorKinesin-like protein KIF11, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywordsksp, ksp-inhibitor complex, cell cycle
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P52732
Total number of polymer chains2
Total molecular weight83460.57
Authors
Yan, Y. (deposition date: 2006-01-05, release date: 2006-02-07, Last modification date: 2011-07-13)
Primary citation
Fraley, M.E.,Garbaccio, R.M.,Arrington, K.L.,Hoffman, W.F.,Tasber, E.S.,Coleman, P.J.,Buser, C.A.,Walsh, E.S.,Hamilton, K.,Fernandes, C.,Schaber, M.D.,Lobell, R.B.,Tao, W.,South, V.J.,Yan, Y.,Kuo, L.C.,Prueksaritanont, T.,Shu, C.,Torrent, M.,Heimbrook, D.C.,Kohl, N.E.,Huber, H.E.,Hartman, G.D.
Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.
Bioorg.Med.Chem.Lett., 16:1775-1779, 2006
PubMed: 16439123 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2006.01.030
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers110.6%4.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report