2FIL

Crystal Structure Analysis of the A-DNA Decamer GCGT-2'OMeA-faT-ACGC, with Incorporated 2'-O-Methylated-Adenosine (2'OMeA) and 2'-Fluoroarabino-Thymidine (faT)

2FIL の概要

• エントリーDOI: 10.2210/pdb2fil/pdb
• 関連するPDBエントリー: 2FIH 2FII 2FIJ
• 分子名称: 5'-D(*GP*CP*GP*TP*(A2M)P*(TAF)P*AP*CP*GP*C)-3', COBALT HEXAMMINE(III) (3 entities in total)
• 機能のキーワード: 2'-fluoroarabino acid, sugar modifications, a-form dna, dna
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 13499.90

構造登録者

Egli, M.,Li, F. (登録日: 2005-12-29, 公開日: 2006-05-23, 最終更新日: 2023-08-30)

• 主引用文献: Li, F.,Sarkhel, S.,Wilds, C.J.,Wawrzak, Z.,Prakash, T.P.,Manoharan, M.,Egli, M.; 2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H.; Biochemistry, 45:4141-4152, 2006; PubMed: 16566588; DOI: 10.1021/bi052322r

実験手法

X-RAY DIFFRACTION (1.69 Å)