2FGI
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 1 IN COMPLEX WITH INHIBITOR PD173074
Summary for 2FGI
Entry DOI | 10.2210/pdb2fgi/pdb |
Descriptor | PROTEIN (FIBROBLAST GROWTH FACTOR (FGF) RECEPTOR 1), 1-TERT-BUTYL-3-[6-(3,5-DIMETHOXY-PHENYL)-2-(4-DIETHYLAMINO-BUTYLAMINO)-PYRIDO[2,3-D]PYRIMIDIN-7-YL]-UREA (3 entities in total) |
Functional Keywords | protein kinase, tyrosine-protein kinase, atp-binding, phosphorylation, inhibitor, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P11362 |
Total number of polymer chains | 2 |
Total formula weight | 71664.57 |
Authors | Mohammadi, M.,Froum, S.,Hamby, J.M.,Schroeder, M.,Panek, R.L.,Lu, G.H.,Eliseenkova, A.V.,Green, D.,Schlessinger, J.,Hubbard, S.R. (deposition date: 1998-09-15, release date: 1999-09-13, Last modification date: 2023-12-27) |
Primary citation | Mohammadi, M.,Froum, S.,Hamby, J.M.,Schroeder, M.C.,Panek, R.L.,Lu, G.H.,Eliseenkova, A.V.,Green, D.,Schlessinger, J.,Hubbard, S.R. Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. EMBO J., 17:5896-5904, 1998 Cited by PubMed: 9774334DOI: 10.1093/emboj/17.20.5896 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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