2FGI
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 1 IN COMPLEX WITH INHIBITOR PD173074
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROTEIN (FIBROBLAST GROWTH FACTOR (FGF) RECEPTOR 1) | polymer | 310 | 35308.6 | 2 | UniProt (P11362) Pfam (PF07714) | Homo sapiens (human) | FGFR1K |
| 2 | C, D (A, B) | 1-TERT-BUTYL-3-[6-(3,5-DIMETHOXY-PHENYL)-2-(4-DIETHYLAMINO-BUTYLAMINO)-PYRIDO[2,3-D]PYRIMIDIN-7-YL]-UREA | non-polymer | 523.7 | 2 | Chemie (PD1) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 191 | Chemie (HOH) |
Sequence modifications
A, B: 456 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Val 457 | Leu 457 | engineered mutation |
| Ala 488 | Cys 488 | engineered mutation |
| Ser 584 | Cys 584 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70617.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1047.3 | |
| All* | Total formula weight | 71664.6 |
