2FDB
Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c
Summary for 2FDB
Entry DOI | 10.2210/pdb2fdb/pdb |
Descriptor | fibroblast growth factor 8 isoform B, Fibroblast growth factor receptor 2 (3 entities in total) |
Functional Keywords | beta-trefoil fold; immunoglobulin fold, hormone-growth factor-transferase complex, hormone/growth factor/transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P55075 Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: Q9UQH9 |
Total number of polymer chains | 4 |
Total formula weight | 87329.55 |
Authors | Mohammadi, M.,Olsen, S.K. (deposition date: 2005-12-13, release date: 2006-02-07, Last modification date: 2023-08-30) |
Primary citation | Olsen, S.K.,Li, J.Y.H.,Bromleigh, C.,Eliseenkova, A.V.,Ibrahimi, O.A.,Lao, Z.,Zhang, F.,Linhardt, R.J.,Joyner, A.L.,Mohammadi, M. Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain Genes Dev., 20:185-198, 2006 Cited by PubMed: 16384934DOI: 10.1101/gad.1365406 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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