2FDB

Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c

2FDB の概要

• エントリーDOI: 10.2210/pdb2fdb/pdb
• 分子名称: fibroblast growth factor 8 isoform B, Fibroblast growth factor receptor 2 (3 entities in total)
• 機能のキーワード: beta-trefoil fold; immunoglobulin fold, hormone-growth factor-transferase complex, hormone/growth factor/transferase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P55075; Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: Q9UQH9
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 87329.55

構造登録者

Mohammadi, M.,Olsen, S.K. (登録日: 2005-12-13, 公開日: 2006-02-07, 最終更新日: 2023-08-30)

• 主引用文献: Olsen, S.K.,Li, J.Y.H.,Bromleigh, C.,Eliseenkova, A.V.,Ibrahimi, O.A.,Lao, Z.,Zhang, F.,Linhardt, R.J.,Joyner, A.L.,Mohammadi, M.; Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain; Genes Dev., 20:185-198, 2006; PubMed: 16384934; DOI: 10.1101/gad.1365406

実験手法

X-RAY DIFFRACTION (2.28 Å)